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Request The Product List ofChemokine Receptor (CCR and CXCR) Chemokine Receptor (CCR and CXCR)

Cat. No. Product Name Information
PC-61172

RAMX3

CXCR3 modulator

RAMX3 is a tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM.
PC-61171

FAUC 1104

CXCR3 agonist

FAUC 1104 is a potent, biased allosteric agonist of CXCR3 (pEC50=5.22) that activates solely G proteins, induces chemotaxis, but fails to induce receptor internalization or β-arrestin 2 recruitment.
PC-61170

FAUC 1036

CXCR3 agonist

FAUC 1036 is a potent, biased allosteric agonist of CXCR3 (pEC50=6.64), selectively induces chemotaxis and receptor internalization, and induces β-arrestin 2 recruitment without any stimulation of G proteins.
PC-61090

GSK 163929

CCR5 antagonist

GSK 163929 is a potent, selective CCR5 antagonist and HIV-1 entry inhibitor with pIC50 of 8.37 and 8.46 in HOS and PBL assays, respectively.
PC-61089

GSK 214096

CCR5 antagonist

GSK 214096 potent, selective CCR5 antagonist and HIV-1 entry inhibitor, inhibits HIV-1 glycoprotein 120 (gp120) binds to the CD4+ T-cell receptor.
PC-60972

LMD-009

CCR8 agonist

LMD-009 (LMD 009, LMD009) is a potent, selective, nonpeptide CCR8 agonist that stimulates CCR8-mediated chemotaxis, inositol phosphate accumulation and calcium release with EC50 of 11-87 nM.
PC-60855

LMD-A

LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM.
PC-60779

E 6130

CX3CR1 inhibitor

E6130 is a potent, selective, orally available CX3C chemokine receptor 1 (CX3CR1) modulator that inhibits the fractalkine-induced chemotaxis of human peripheral blood NK cells with IC50 of 4.9 nM.
PC-60672

INCB9471

CCR5 antagonist

INCB9471 is a potent, selective and orally bioavailable CCR5 antagonist IC50 of 6.5 nM, Kd of 3.1 nM in human PBMCs.
PC-60626

CX797

CXCR2 antagonist

CX797 is a potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.
PC-60625

CX815

CXCR2 antagonist

CX815 is a potent, selective CXCR2 inhibitor with IC50 of 0.4 nM.
PC-60624

CX4152

CXCR2 antagonist

CX4152 is a potent, selective CXCR2 inhibitor with IC50 of 7.6 nM, displays>1,000-fold selectivity over CXCR4 (IC50>50 uM).

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