CCR10 antagonist 1 |CAS:1191031-97-6 Probechem Biochemicals

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Chemical Structure : CCR10 antagonist 1

CCR10 antagonist 1

Catalog No.: PC-35029Not For Human Use, Lab Use Only.

CCR10 antagonist 1 is a potent, selective CCR10 antagonist with IC50 of 690 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CCR10 antagonist 1 is a potent, selective CCR10 antagonist with IC50 of 690 nM.
CCR10 antagonist 1 demonstrates functional CCR1 antagonism by inhibiting the CCL27 dependent chemotaxis of Ba/F3 cells stably transfected with human CCR10 with an IC50 of 53 nM.
CCR10 antagonist 1 exhibits no antagonism of murine CCL27 dependent Ca2+ flux in CHO-K cells stably transfected with murine CCR10 at 20 uM.

Physicochemical Properties

M.Wt	519.398
Formula	C19H24Cl2N6O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-amino-3,5-dichloro-N-(1-(4-methylpiperidin-1-yl)-4-(2-nitro-1H-imidazol-1-yl)-1-oxobutan-2-yl)benzenesulfonamide

References

1. Abeywardane A, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283.

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