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You are here:Home-Chemical Inhibitors & Agonists-GPCR-Chemokine Receptor (CCR and CXCR)-BI 6901
BI 6901

Chemical Structure : BI 6901

CAS No.: 2040401-92-9

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BI 6901 (BI6901)

Catalog No.: PC-35030Not For Human Use, Lab Use Only.

BI 6901 is a potent, selective CCR10 antagonist with Aequorin Ca2+ flux pIC50 of 9.0, shows high selectivity over other GPCRs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BI 6901 is a potent, selective CCR10 antagonist with Aequorin Ca2+ flux pIC50 of 9.0, shows high selectivity over other GPCRs.
BI 6901 inhibits the CCL27 dependent chemotaxis of Ba/F3 cells stably transfected with human CCR10 with pIC50 of 9.0.
BI 6901 is efficacious in a murine model of DNFB contact hypersensitivity, inhibits DNFB stimulated inflammatory response in sensitized Balb-C mice.

Physicochemical Properties

M.Wt 453.561
Formula C23H27N5O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(2R)-4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-4-sulfonamide

References

1. Abeywardane A, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283.

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