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TIQ-15

Chemical Structure : TIQ-15

CAS No.: 1380336-17-3

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TIQ-15 (TIQ15)

Catalog No.: PC-35087Not For Human Use, Lab Use Only.

TIQ-15 is a potent and selective CXCR4 antagonist, inhibits attachment of X4 HIV-1IIIB virus in MAGI-CCR5/CXCR4 cells with IC50 of 3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TIQ-15 is a potent and selective CXCR4 antagonist, inhibits attachment of X4 HIV-1IIIB virus in MAGI-CCR5/CXCR4 cells with IC50 of 3 nM.
    TIQ-15 inhibits calcium release in Chem-1 cells with IC50 of 3 nM.
    TIQ-15 shows no cross-activity in a panel of chemokine receptor assays in both CXCR and CCR types.

    Physicochemical Properties

    M.Wt 364.537
    Formula C23H32N4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-N1-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine

    References

    1. Truax VM, et al. ACS Med Chem Lett. 2013 Sep 5;4(11):1025-30.

    2. Yesim A. Tahirovic, et al. ACS Med. Chem. Lett., 2018, 9 (5), pp 446-451.

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