Catalog No.: PC-35036Not For Human Use, Lab Use Only.
BMS-817399 is a potent, selective, orally bioavailable CCR1 antagonist with binding IC50 of 1 nM, inhibits MIP-1α-induced chemotaxis with IC50 of 6 nM.
BMS-817399 is a potent, selective, orally bioavailable CCR1 antagonist with binding IC50 of 1 nM, inhibits MIP-1α-induced chemotaxis with IC50 of 6 nM.
BMS-817399 shows no binding activity to other CC family receptors, including CCR2, CCR3, CCR4, CCR5, CXCR2, CXCR3, and CXCR5, as well as a broad panel of other GPCRs and biogenic amine transporters.
BMS-817399 blocks MIP1α- and LKN-1-mediated up-regulation of CD11b in human whole blood with IC50 values of 25 nM and 42 nM, respectively.
BMS-817399 shows potential for the treatment of rheumatoid arthritis.
