Chemical Structure : Elubrixin tosylate
CAS No.:
960495-43-6
Elubrixin tosylate
(SB-656933, GSK656933)
Catalog No.: PC-62990Not For Human Use, Lab Use Only.
Elubrixin tosylate (SB-656933, GSK656933) is a potent, selective, competitive and reversible CXCR2 antagonist.
| Packing | Price | Stock | Quantity |
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | | Get quote | |
| 100 mg | | Get quote | |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Select Batch:
Biological Activity
Elubrixin tosylate (SB-656933, GSK656933) is a potent, selective, competitive and reversible CXCR2 antagonist.
Elubrixin inhibits CXCL1-induced CD11b up-regulation on PMNs with IC50 of 26.07 nM in in vitro whole blood assay.
Elubrixin is active in in vivo rodent inhalation challenge models of airway inflammation that used endotoxin and ozone to induce airway neutrophilia.
Physicochemical Properties
|
M.Wt
|
635.503
|
|
Formula
|
C24H25Cl2FN4O7S2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20 °C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80 °C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
1-(2-chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea tosylate
|
References
1. Lazaar AL, et al. Br J Clin Pharmacol. 2011 Aug;72(2):282-93.
2. Nicholson GC, et al. Pulm Pharmacol Ther. 2007;20(1):52-9.
3. Kaur M, et al. J Pharmacol Exp Ther. 2013 Oct;347(1):173-80.
4. Busch-Petersen J, et al. Curr Top Med Chem. 2006;6(13):1345-52.
Contact Us
sales@probechem.com
