AF-399 42016530 |CAS:618864-56-5 Probechem Biochemicals

Chemical Structure : AF-399 42016530

AF-399 42016530 (AF-399/42016530)

Catalog No.: PC-61466Not For Human Use, Lab Use Only.

AF-399/42016530 is a potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.

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Biological Activity

AF-399/42016530 is a potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.
AF-399/42016530 enhances DC-mediated human CD4(+) T cell proliferation in an in vitro immune response model and amplifies cellular and humoral immune responses in vivo in experimental models.
AF-399/42016530 induces antigen-specific CD8+ T cells and tumor immunity against self antigens in combination with vaccines.

Physicochemical Properties

M.Wt	531.619
Formula	C26H17N3O4S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-benzofuran-2-ylcarbonyl)-1-[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]-3-hydroxy-5-(2-thienyl)-1,5-dihydro-2H-pyrrol-2-one.

References

1. Klein A, et al. Oncotarget. 2017 May 9;8(19):31079-31091.

2. Bayry J, et al. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10221-6.

3. Pere H, et al. Blood. 2011 Nov 3;118(18):4853-62.

AF-399 42016530 (AF-399/42016530)

Biological Activity

Physicochemical Properties

References

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