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Chemical Structure : AF-399 42016530
Catalog No.: PC-61466Not For Human Use, Lab Use Only.
AF-399/42016530 is a potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.
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AF-399/42016530 is a potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.
AF-399/42016530 enhances DC-mediated human CD4(+) T cell proliferation in an in vitro immune response model and amplifies cellular and humoral immune responses in vivo in experimental models.
AF-399/42016530 induces antigen-specific CD8+ T cells and tumor immunity against self antigens in combination with vaccines.
| M.Wt | 531.619 | |
| Formula | C26H17N3O4S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Klein A, et al. Oncotarget. 2017 May 9;8(19):31079-31091.
2. Bayry J, et al. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10221-6.
3. Pere H, et al. Blood. 2011 Nov 3;118(18):4853-62.
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