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PF-04634817 succinate

Chemical Structure : PF-04634817 succinate

CAS No.: 2140301-98-8

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PF-04634817 succinate (PF4634817 succinate)

Catalog No.: PC-61559Not For Human Use, Lab Use Only.

PF-04634817 succinate is a potent, orally bioavailble CCR2 and CCR5 chemokine receptor antagonist with IC50 of 20.8 nM (human and rodent CCR2), 470 nM (rat CCR5).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-04634817 succinate is a potent, orally bioavailble CCR2 and CCR5 chemokine receptor antagonist with IC50 of 20.8 nM (human and rodent CCR2), 470 nM (rat CCR5).
    PF-04634817 shows potential for the treatment of diabetic nephropathies and diabetic macular oedema.

    Physicochemical Properties

    M.Wt 629.67
    Formula C25H36F3N5O3 · C4H6O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((1S,3R)-1-isopropyl-3-(((3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl)amino)cyclopentyl)((1S,4S)-5-(6-(trifluoromethyl)pyrimidin-4-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methanone succinate

    References

    1. Tesch GH, et al. Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1439-F1449.
    2. Gale JD, et al. Kidney Int Rep. 2018 Aug 3;3(6):1316-1327.

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