Chemical Structure : PF-04136309
CAS No.:
1341224-83-6
PF-04136309
(INCB8761;PF-4136309;PF4136309;PF 4136309;INCB-8761)
Catalog No. : PC-61557Not For Human Use, Lab Use Only.
PF-4136309 (INCB8761) is a potent, selective, competitive, reversible full CCR2 antagonist with IC50 of 2-5 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6155701
Biological Activity
PF-4136309 (INCB8761) is a potent, selective, competitive, reversible full CCR2 antagonist with IC50 of 2-5 nM.
Physicochemical Properties
M.Wt
568.59
Formula
C29H31F3N6O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
References
1. Sanford DE, et al. Clin Cancer Res. 2013 Jul 1;19(13):3404-15.
2. Nywening TM, et al. Lancet Oncol. 2016 May;17(5):651-62.
3. Xue CB, et al. ACS Med Chem Lett. 2011 Oct 5;2(12):913-8.
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