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AZ 13381758

Chemical Structure : AZ 13381758

CAS No.:

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AZ 13381758 (AZ13381758;CXCR2 SM;AZ-13381758)

Catalog No.: PC-60616Not For Human Use, Lab Use Only.

A potent, small molecule CXCR2 inhibitor with IC50 of 26 nM and 30 nM for mCXCR2 and hCXCR2, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AZ 13381758 is a potent, small molecule CXCR2 inhibitor with IC50 of 26 nM and 30 nM for mCXCR2 and hCXCR2, respectively.
AZ 13381758 inhibits the growth and metastatic potential pancreatic ductal adenocarcinoma, enhances sensitivity to anti-PD1 immunotherapy in vivo; chemical analog of AZD 5069.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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