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CX4152

Chemical Structure : CX4152

CAS No.: 333351-27-2

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CX4152 (CX 4152, CX-4152)

Catalog No.: PC-60624Not For Human Use, Lab Use Only.

CX4152 is a potent, selective CXCR2 inhibitor with IC50 of 7.6 nM, displays>1,000-fold selectivity over CXCR4 (IC50>50 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CX4152 is a potent, selective CXCR2 inhibitor with IC50 of 7.6 nM, displays>1,000-fold selectivity over CXCR4 (IC50>50 uM).
    CX4152 inhibits CXCR2 signaling through downregulation of surface CXCR2.
    CX4152 significantly inhibits CXCL8-mediated neutrophil migration and LPS-induced lung inflammation in mice.
    CX4152 inhibits CXCR2/β-arrestin-2 association, cell migration and proliferation, and acute inflammation in mouse models.

    Physicochemical Properties

    M.Wt 435.538
    Formula C25H25NO4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-acetyl-2-methylnaphtho[1,2-b]furan-5-yl)-4-(tert-butyl)benzenesulfonamide

    References

    1. Ha H, et al. J Chem Inf Model. 2015 Aug 24;55(8):1720-38.

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