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SB 265610

Chemical Structure : SB 265610

CAS No.: 211096-49-0

SB 265610 (SB265610;SB-265610)

Catalog No.: PC-60621Not For Human Use, Lab Use Only.

SB 265610 is a potent, selective, reversible CXCR2 antagonist with with Kd of 3.48 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SB 265610 is a potent, selective, reversible CXCR2 antagonist with with Kd of 3.48 nM.
SB 265610 inhibits protein nitration induced by hyperoxia, reduces radical formation in hyperoxia-exposed newborn rat lung.
SB 265610 also induces G1 arrest, ans shows anti-proliferative activity in in IL8-rich tumor microenvironments.

Physicochemical Properties

M.Wt 357.16
Formula C14H9BrN6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in DMSO

Chemical Name/SMILES

N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea

References

1. de Kruijf P, et al. J Pharmacol Exp Ther. 2009 May;329(2):783-90.

2. Bradley ME, et al. Br J Pharmacol. 2009 Sep;158(1):328-38.

3. de Kruijf P, et al. Mol Pharmacol. 2011 Dec;80(6):1108-18.

4. Goda AE, et al. Anticancer Res. 2015 Jun;35(6):3235-43.

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