Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-GPCR-Chemokine Receptor (CCR and CXCR)-MK-0812
MK-0812

Chemical Structure : MK-0812

CAS No.: 624733-88-6

Add to Favorites

MK-0812 (MK 0812;MK0812)

Catalog No.: PC-45833Not For Human Use, Lab Use Only.

MK-0812 is a potent CCR2 specific antagonist that blocks MCP-1 mediated response with an IC50 of 3.2 nM.

Packing Price Stock Quantity
5 mg Get quote
10 mg Get quote
25 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MK-0812 is a potent CCR2 specific antagonist that blocks MCP-1 mediated response with an IC50 of 3.2 nM.
MK-0812 inhibits 125I-MCP-1 binding on isolated monocytes with IC50 of 4.5 nM.
MK-0812 reduces macrophage accumulation in adipose tissue in ob/ob mice.

Physicochemical Properties

M.Wt 469.5403
Formula C24H34F3N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

D-erythro-Pentitol, 1,5-anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-

References

1. Wisniewski T, et al. J Immunol Methods. 2010 Jan 31;352(1-2):101-10.

2. O'Brien PD, et al. Diabetes Obes Metab. 2017 Mar 23. doi: 10.1111/dom.12950.

3. Min SH, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: