Chemical Structure : MK-0812 succinate
CAS No.:
851916-42-2
MK-0812 succinate
(MK 0812 Succinate;MK0812 Succinate)
Catalog No. : PC-45834Not For Human Use, Lab Use Only.
A potent CCR2 specific antagonist that blocks MCP-1 mediated response with an IC50 of 3.2 nM.
Packing Price Stock Quantity 10 mg $224 In stock 0 1 2 3 4 5 50 mg $784 In stock 0 1 2 3 4 5 100 mg $1240 In stock 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4583401
Biological Activity
A potent CCR2 specific antagonist that blocks MCP-1 mediated response with an IC50 of 3.2 nM; inhibits 125I-MCP-1 binding on isolated monocytes with IC50 of 4.5 nM; reduces macrophage accumulation in adipose tissue in ob/ob mice.
Multiple Sclerosis
Phase 2 Discontinued
Physicochemical Properties
M.Wt
587.6283
Formula
C28H40F3N3O7
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 32 mg/mL
Chemical Name/SMILES
D-erythro-Pentitol, 1,5-anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-, butanedioate (1:1)
References
1. Wisniewski T, et al. J Immunol Methods. 2010 Jan 31;352(1-2):101-10.
2. O'Brien PD, et al. Diabetes Obes Metab. 2017 Mar 23. doi: 10.1111/dom.12950.
3. Min SH, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6.
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