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RS102895 hydrochloride

Chemical Structure : RS102895 hydrochloride

CAS No.: 1173022-16-6

RS102895 hydrochloride (RS 102895 hydrochloride)

Catalog No.: PC-45482Not For Human Use, Lab Use Only.

RS102895 hydrochloride is a potent and specific CCR2 antagonist with binding IC50 of 360 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RS102895 hydrochloride is a potent and specific CCR2 antagonist with binding IC50 of 360 nM.
RS102895 shows no significant affinity on CXCR1, CCR1, or CCR3. (IC50>17 uM).
RS102895 inhibits MCP-1-stimulated calcium influx into CCR2-CHL cells with IC50 of 32 nM.
RS102895 significantly attenuates HG-induced ECM protein expression and TGF-beta1 levels in mouse mesangial cells (MCs).

Physicochemical Properties

M.Wt 426.8598
Formula C21H22ClF3N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 28 mg/mL

Chemical Name/SMILES

Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)

References

1. Mirzadegan T, et al. J Biol Chem. 2000 Aug 18;275(33):25562-71.

2. Park J, et al. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57.

3. Hung YW, et al. J Neuroinflammation. 2013 Jan 22;10:11.

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