Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-GPCR-Chemokine Receptor (CCR and CXCR)-RS102895 hydrochloride
RS102895 hydrochloride

Chemical Structure : RS102895 hydrochloride

CAS No.: 1173022-16-6

RS102895 hydrochloride (RS 102895 hydrochloride)

Catalog No.: PC-45482Not For Human Use, Lab Use Only.

RS102895 hydrochloride is a potent and specific CCR2 antagonist with binding IC50 of 360 nM.

Packing Price Stock Quantity
10 mg $118 In stock
25 mg $198 In stock
50 mg $328 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RS102895 hydrochloride is a potent and specific CCR2 antagonist with binding IC50 of 360 nM.
RS102895 shows no significant affinity on CXCR1, CCR1, or CCR3. (IC50>17 uM).
RS102895 inhibits MCP-1-stimulated calcium influx into CCR2-CHL cells with IC50 of 32 nM.
RS102895 significantly attenuates HG-induced ECM protein expression and TGF-beta1 levels in mouse mesangial cells (MCs).

Physicochemical Properties

M.Wt 426.8598
Formula C21H22ClF3N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL

Chemical Name/SMILES

Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)

References

1. Mirzadegan T, et al. J Biol Chem. 2000 Aug 18;275(33):25562-71.

2. Park J, et al. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57.

3. Hung YW, et al. J Neuroinflammation. 2013 Jan 22;10:11.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: