IT1t (Isothiourea 1t) is a highly potent, selective, orally bioavailable CXCR4 inhibitor with binding IC50 of 8 nM for hCXCR4, IC50 of 1.1 nM in Ca2+-mobilization assays.
IT1t inhibits HIV-1IIIB attachment with IC50 of 7 nM, and IC90 of 100 nM.
IT1t also show promising anti-tumor effects, impairs the formation of TNBC early metastases in a zebrafish xenograft model.
