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AZD-4818

Chemical Structure : AZD-4818

CAS No.: 1003566-93-5

AZD-4818 (AZD4818)

Catalog No.: PC-62762Not For Human Use, Lab Use Only.

AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner.

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10 mg $188 In stock
25 mg $298 In stock
50 mg $458 In stock
100 mg $758 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner.
AZD-4818 significantly reduces neutrophil influx and TNF-α levels on bronchoalveolar lavage (BAL) following intratracheal administration in vivo.

Physicochemical Properties

M.Wt 567.46
Formula C27H32Cl2N2O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[2-Chloro-5-[(2S)-3-(5-chlorospiro[benzofuran-2(3H),4'-piperidin]-1'-yl)-2-hydroxypropoxy]-4-[(methylamino)carbonyl]phenoxy]-2-methylpropanoic acid

References

1. Kerstjens HA, et al. Respir Med. 2010 Sep;104(9):1297-303.

2. Norman P. Expert Opin Ther Pat. 2009 Nov;19(11):1629-33.

3. Gilchrist A, et al. Br J Pharmacol. 2014 Nov;171(22):5127-38.

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