Catalog No.: PC-23972Not For Human Use, Lab Use Only.
Reparixin L-lysine salt (Repertaxin) is a potent, selective, non-competitive allosteric inhibitor of CXCL8 receptor CXCR1 and CXCR2 activation with IC50 of 1 nM and 100 nM, respectively.
Reparixin L-lysine salt (Repertaxin) is a potent, selective, non-competitive allosteric inhibitor of CXCL8 receptor CXCR1 and CXCR2 activation with IC50 of 1 nM and 100 nM, respectively. Reparixin inhibited the chemotaxis of neutrophils induced by human CXCL8 or rat CINC-1, but not that induced by fMLP, PAF or LTB(4), in a concentration-dependent manner. Reparixin also prevented CXCL8-induced calcium influx but not CXCL8 binding to purified rat neutrophils. Reparixin dose-dependently (3-30 mg kg(-1)) inhibited the increase in vascular permeability and neutrophil influx. Reparixin effectively suppressed the increase in tissue (intestine and lungs) and serum concentrations of TNF-alpha and the reperfusion-associated lethality.
Physicochemical Properties
M.Wt
428.57
Formula
C20H34N3O5S-
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(R)-2-(4-Isobutylphenyl)-N-(methylsulfonyl)propanamide L-lysine salt
References
1. Moriconi A, et al. J Med Chem. 2007 Aug 23;50(17):3984-4002.
2. Garau A, et al. Eur Cytokine Netw. 2006 Mar;17(1):35-41.
3. Bertini R, et al. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6.
