SQA1

Chemical Structure : SQA1

Catalog No.: PC-23011Not For Human Use, Lab Use Only.

SQA1 is a small molecule allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.7, also inhibits CXCR2.

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Biological Activity

SQA1 is a small molecule allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.7, also inhibits CXCR2.
SQA1 binds to an intracellular pocket of CCR6.

Physicochemical Properties

M.Wt	426.47
Formula	C22H26N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Hydroxy-N,N-dimethyl-4-[[2-[[(1R)-1-[4-(1-methylethyl)-2-furanyl]propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-2-pyridinecarboxamide

References

1. Wasilko DJ, et al. Nat Commun. 2024 Aug 31;15(1):7574.

2. Li, W. et al. J. Pharm. Exp. Ther. 386, 80–92 (2023).

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SQA1

Biological Activity

Physicochemical Properties

References

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