OXM2 | CCR6 inhibitor | Probechem Biochemicals

Chemical Structure : OXM2

OXM2 (CCR6 antagonist)

Catalog No.: PC-23013Not For Human Use, Lab Use Only.

OXM2 is a highly selective, allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.78.

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Biological Activity

OXM2 is a highly selective, allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.78.
OXM2 is not active against other chemokine receptors (CKRs).

Physicochemical Properties

M.Wt	408.42
Formula	C21H23F3N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-((4-(bicyclo[1.1.1]pentan-1-yl)-5-oxomorpholin-2-yl)methyl)-1-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

References

1. Wasilko DJ, et al. Nat Commun. 2024 Aug 31;15(1):7574.

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OXM2 (CCR6 antagonist)

Biological Activity

Physicochemical Properties

References

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