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AZ084

Chemical Structure : AZ084

CAS No.: 929300-19-6

AZ084 (AZ-084)

Catalog No.: PC-35514Not For Human Use, Lab Use Only.

AZ084 (AZ-084) is a potent, selective, allosteric, orally available CCR8 antagonist with Ki of 0.9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZ084 (AZ-084) is a potent, selective, allosteric, orally available CCR8 antagonist with Ki of 0.9 nM.
AZ084 demonstrates excellent selectivity in a panel of 141 kinases and receptors, also shows no binding activity at 10 uM towards any of the other chemokine receptors.
AZ084 demonstrates excellent selectivity, high metabolic stability in vitro and an attractive in vivo PK profile with a long half-life in rats; inhibits dendritic cell, T cell and eosinophil migration.

Physicochemical Properties

M.Wt 434.584
Formula C26H34N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(5-aminopyridin-2-yl)(9-((2,2-dimethyl-2,3-dihydrobenzofuran-4-yl)methyl)-3,9-diazaspiro[5.5]undecan-3-yl)methanone

References

1. Connolly S, et al. Biochem Pharmacol. 2012 Mar 15;83(6):778-87.

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