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BMS-570520

Chemical Structure : BMS-570520

CAS No.: 388101-58-4

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BMS-570520 (BMS 570520)

Catalog No.: PC-73261Not For Human Use, Lab Use Only.

BMS-570520 is a potent, selective CCR3 antagonist with IC50 of 1.9 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.068 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-570520 is a potent, selective CCR3 antagonist with IC50 of 1.9 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.068 nM.
    BMS-570520 displays reduced inhibition on CYP2D6 (IC50=1300 nM) compared with DPC168 (IC50=30 nM), also possesses >100-fold selectivity over 5-HT2a, DAT and NET.
    BMS-570520 showed good activity in murine models of CCR3 antagonism and greater in vitro potency and in vivo in the mouse intranasal eotaxin challenge mode.

    Physicochemical Properties

    M.Wt 529.675
    Formula C27H36FN5O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Urea, N-[(3S,4S)-1-acetyl-4-[[(3S)-3-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl]-3-piperidinyl]-N'-(5-acetyl-4-methyl-2-thiazolyl)-

    References

    1. James R Pruitt, et al. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2992-7.

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