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DPC168

Chemical Structure : DPC168

CAS No.: 275810-55-4

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DPC168 (DPC-168)

Catalog No.: PC-73260Not For Human Use, Lab Use Only.

DPC168 (DPC-168) is a highly potent, selective CC chemokine receptor-3 (CCR3) antagonist with IC50 of 2.0 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.034 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DPC168 (DPC-168) is a highly potent, selective CC chemokine receptor-3 (CCR3) antagonist with IC50 of 2.0 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.034 nM.
    DPC168 demonstrates potency for mouse CCR3 (chemotaxis IC50=41 nM) and oral bioavailability in mice (20% F).
    DPC168 reduced eosinophil recruitment into the lungs in a dose-dependent manner in these animal models.

    Physicochemical Properties

    M.Wt 465.613
    Formula C28H36FN3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Urea, N-(3-acetylphenyl)-N'-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl]cyclohexyl]-

    References

    1. De Lucca GV, et al. J Med Chem. 2005 Mar 24;48(6):2194-211.

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