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Chemical Structure : DPC168
Catalog No.: PC-73260Not For Human Use, Lab Use Only.
DPC168 (DPC-168) is a highly potent, selective CC chemokine receptor-3 (CCR3) antagonist with IC50 of 2.0 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.034 nM.
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DPC168 (DPC-168) is a highly potent, selective CC chemokine receptor-3 (CCR3) antagonist with IC50 of 2.0 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.034 nM.
DPC168 demonstrates potency for mouse CCR3 (chemotaxis IC50=41 nM) and oral bioavailability in mice (20% F).
DPC168 reduced eosinophil recruitment into the lungs in a dose-dependent manner in these animal models.
| M.Wt | 465.613 | |
| Formula | C28H36FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. De Lucca GV, et al. J Med Chem. 2005 Mar 24;48(6):2194-211.
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