IS811 | CCR3 antagonist | Probechem Biochemicals

Chemical Structure : IS811

IS811 (IS 811, IS-811)

Catalog No.: PC-73259Not For Human Use, Lab Use Only.

IS811 is a potent, selective CCR3 antagonist with IC50 of 2.0 nM, potently inhibits chemotaxis with EC50 of 19 nM.

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Biological Activity

IS811 is a potent, selective CCR3 antagonist with IC50 of 2.0 nM, potently inhibits chemotaxis with EC50 of 19 nM.
IS811 displays >100-fold selectivity over 5-HT2a, DAT and NET.
IS811 (0-20 mg/kg) dose-dependently inhibited eotaxin-induced eosinophil influx to the lung in vivo.

Physicochemical Properties

M.Wt	453.602
Formula	C27H36FN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-(3-acetylphenyl)-N'-[3-[(2S,4R)-4-[(4-fluorophenyl)methyl]-1-propyl-2-piperidinyl]propyl]-

References

1. Paul S Watson, et al. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5695-9.

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IS811 (IS 811, IS-811)

Biological Activity

Physicochemical Properties

References

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