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Chemical Structure : RS-1269
Catalog No.: PC-73264Not For Human Use, Lab Use Only.
RS-1269 is a highly potent, selective CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 27.7 nM.
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RS-1269 is a highly potent, selective CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 27.7 nM.
RS-1269 also has strong affinity to displace the CCL17 binding with IC50 of 27.0 nM in CCR4-expressing CHO cells.
RS-1269 displays no competitive displacement in the binding of [125I]CCL3 (MIP-1α) to CCR1 and [125I]CCL2 (MCP-1) to CCR2b.
RS-1269 dose-dependently inhibited CCL17-induced migration of Th2 cells with IC50 of 5.5 nM.
Orally administered RS-1269 (30 mg/kg) ameliorates ovalbumin-induced ear swelling in mice.
RS-1269 also inhibited LPS-induced TNF-α production in vivo.
| M.Wt | 562.714 | |
| Formula | C35H38N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nakagami Y, et al. Basic Clin Pharmacol Toxicol. 2010 Oct;107(4):793-7.
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