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Chemical Structure : CCR4-IN-22
Catalog No.: PC-73263Not For Human Use, Lab Use Only.
CCR4-IN-22 (Compound 22) is a potent, selective CCR4 antagonist with IC50 of 20 nM, efficiently inhibits CCR4-mediated Ca2+ mobilization and chemotaxis in vitro with IC50 of 3 and 7 nM, repectively.
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CCR4-IN-22 (Compound 22) is a potent, selective CCR4 antagonist with IC50 of 20 nM, efficiently inhibits CCR4-mediated Ca2+ mobilization and chemotaxis in vitro with IC50 of 3 and 7 nM, repectively.
Compound 22 displays >500-fold less effective against other chemokine receptors (CCR2, CCR3 and CXCR3). and GPCRs (5-HT1A, 5-HT6 and 5-HT7).
Compound 22 suppressed eosinophil accumulation in the lungs of antigenimmunized mice in vivo, efficacious in a murine allergic inflammation model (ED50 10 mg/kg).
Compound 22, as well as anti-CCL17 or anti-CCL22 antibody selectively suppressed accumulation of Th2 cells and eosinophils in the lungs of Th2-transferred and OVA-challenged mice.
Compound 22 also inhibited bronchial hyperresponsiveness but had little effect on goblet cell hyperplasia in Th2-transferred and OVA-challenged mice.
| M.Wt | 500.428 | |
| Formula | C24H27Cl2N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ashok V Purandare, et al. Bioorg Med Chem Lett. 2007 Feb 1;17(3):679-82.
2. O Kaminuma, et al. Clin Exp Allergy. 2012 Feb;42(2):315-25.
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