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GSK2239633A

Chemical Structure : GSK2239633A

CAS No.: 1240516-71-5

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GSK2239633A (GSK2239633)

Catalog No.: PC-73262Not For Human Use, Lab Use Only.

GSK2239633A is a potent, allosteric CC-chemokine receptor 4 (CCR4) antagonist with pIC50 of 7.83 in 35S-GTPγS competition assay.

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10 mg $218 In stock
25 mg $378 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK2239633A is a potent, allosteric CC-chemokine receptor 4 (CCR4) antagonist with pIC50 of 7.83 in 35S-GTPγS competition assay.
GSK2239633A binds to CCR4 at an intracellular allosteric site denoted site II. GSK2239633A inhibits thymus activation-regulated chemokine (TARC) -induced F-actin polymerization in human whole blood.

Physicochemical Properties

M.Wt 549.06
Formula C24H25ClN4O5S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-((3-((5-chlorothiophene)-2-sulfonamido)-4-methoxy-1H-indazol-1-yl)methyl)benzyl)-2-hydroxy-2-methylpropanamide

References

1. Procopiou PA, et al. J Med Chem. 2013 Mar 14;56(5):1946-60.

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