Catalog No.: PC-73268Not For Human Use, Lab Use Only.
NBI-74330 is a potent, selective CXC chemokine receptor 3 (CXCR3) antagonist, inhibits [(125)I]CXCL10 and [(125)I]CXCL11 specific binding with Ki of 1.5 and 2.3 nM, respectively.
NBI-74330 (VUF10472) is a potent, selective CXC chemokine receptor 3 (CXCR3) antagonist, inhibits [(125)I]CXCL10 and [(125)I]CXCL11 specific binding with Ki of 1.5 and 2.3 nM, respectively.
NBI-74330 exhibited specific inhibition of functional responses mediated by CXCR3, such as ligand-induced guanosine 5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding, calcium mobilization, and cellular chemotaxis (IC50=7-18 nM).
NBI-74330 showed no significant inhibition of chemotactic responses to other chemokines and did not inhibit radioligand binding to a panel of nonchemokine G-protein coupled receptors.
NBI-74330 block CXCR3-mediated signaling in peritonitis and diet-induced atherosclerosis, attenuates atherosclerotic plaque formation in LDL receptor-deficient mice。
