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CTCE-9908

Chemical Structure : CTCE-9908

CAS No.: 1030384-98-5

CTCE-9908 (CTCE9908)

Catalog No.: PC-23668Not For Human Use, Lab Use Only.

CTCE-9908 is a potent and selective CXCR4 antagonist, induces mitotic catastrophe in ovarian cancer cells.

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Biological Activity

CTCE-9908 is a potent and selective CXCR4 antagonist, induces mitotic catastrophe in ovarian cancer cells.
CTCE-9908 inhibits migration and growth in CXCR4-expressing ovarian cancer cells.
CTCE-9908 induces multinucleation and G2-M arrest in ovarian cancer cells.
CTCE-9908 induces DNA re-replication and abnormal mitoses in ovarian cancer cells.
CTCE-9908 significantly reduced lung metastasis of osteosarcoma and melanoma cells in animal models.

Physicochemical Properties

M.Wt 1927.29
Formula C86H147N27O23
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Lysinamide, N2,N6-bis(L-lysylglycyl-L-valyl-L-seryl-L-leucyl-L-seryl-L-tyrosyl-L-arginyl)-

References

1. Kim SY, et al. Clin Exp Metastasis. 2008;25(3):201-11.

2. Porvasnik S, et al. Prostate. 2009 Sep 15;69(13):1460-9.

3. Kwong J, et al. Mol Cancer Ther. 2009 Jul;8(7):1893-905.

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