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Chemical Structure : PS372424
CAS No.: 914291-61-5
Catalog No.: PC-21814Not For Human Use, Lab Use Only.
PS372424 is a potent, selective peptidomimetic agonist of human CXC chemokine receptor 3 (CXCR3) with EC50 of 1.1 uM in calcium flux assays, binding affinity of 42 nM.
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|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $588 | In stock | |
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| 100 mg | Get quote |
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PS372424 is a potent, selective peptidomimetic agonist of human CXC chemokine receptor 3 (CXCR3) with EC50 of 1.1 uM in calcium flux assays, binding affinity of 42 nM.
Unlike CXCL11, PS372424 does not stimulate transendothelial T-cell migration.
PS372424 is specific for human CXCR3 but does not activate murine CXCR3.
PS372424 activates ERK in T cells with a similar potency and kinetic to the natural ligand CXCL11.
PS372424 inhibits the migration of T cells toward CXCL11, CXCL12, and CCL5, whereas the CXCR3 antagonist NBI-74330 (Cat#PC-73268) only prevented migration toward CXCL11.
PS372424 demonstrates potent anti-inflammatory activity both in vitro and in a novel humanized in vivo model of rheumatoid arthritis.
| M.Wt | 588.75 | |
| Formula | C33H44N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-N-((S)-1-((cyclohexylmethyl)amino)-5-guanidino-1-oxopentan-2-yl)-2-(4-oxo-4-phenylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide |
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1. Graeme O'Boyle, et al. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4598-603.
2. Stroke IL, et al. Biochem Biophys Res Commun. 2006;349:221–228.
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