Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-GPCR-Chemokine Receptor (CCR and CXCR)-IDOR-1117-2520
IDOR-1117-2520

Chemical Structure : IDOR-1117-2520

CAS No.: 2737274-49-4

IDOR-1117-2520

Catalog No.: PC-22322Not For Human Use, Lab Use Only.

IDOR-1117-2520 is a potent, selective CCR6 antagonist with IC50 of 62.9 nM for CCL20-mediated calcium flow inhibition in FLIPR calcium mobilization assay.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IDOR-1117-2520 is a potent, selective CCR6 antagonist with IC50 of 62.9 nM for CCL20-mediated calcium flow inhibition in FLIPR calcium mobilization assay.
IDOR-1117-2520 shows no inhibitory activity at 10 μM for any of the tested related chemokine receptors (CCR5, CCR7, CCR8, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR6). 
IDOR-1117-2520 has IC50 of 20 nM in functional assay of receptor internalization (RI) performed in human whole blood.
IDOR-1117-2520 inhibits β-arrestin recruitment to human CCR6 induced by the addition of CCL20.
IDOR-1117-2520 (50 nM) inhibited cell migration toward CCL20 by 40 and 50% of the maximal migration for B cells and T cells, respectively.

Physicochemical Properties

M.Wt 436.56
Formula C25H32N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)propan-2-ol

References

1. Meyer EA, et al. J Med Chem. 2024 May 10. doi: 10.1021/acs.jmedchem.4c00186.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: