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OXM1

Chemical Structure : OXM1

CAS No.:

OXM1 (CCR6 antagonist)

Catalog No.: PC-23012Not For Human Use, Lab Use Only.

OXM1 is a highly selective, allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.8.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OXM1 is a highly selective, allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.8.
OXM1 is not active against other chemokine receptors (CKRs).

Physicochemical Properties

M.Wt 424.93
Formula C24H25ClN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-1-(4-chlorophenyl)-N-((4-(2,3-dihydro-1H-inden-2-yl)-5-oxomorpholin-2-yl)methyl)cyclopropane-1-carboxamide

References

1. Wasilko DJ, et al. Nat Commun. 2024 Aug 31;15(1):7574.

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