YL410 | GPR15 antagonist | Probechem Biochemicals

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Chemical Structure : YL410

YL410 (YL-410)

Catalog No.: PC-28498Not For Human Use, Lab Use Only.

YL410 is a potent, selective and vivo efficacious antagonist of atypical chemokine receptor GPR15 with IC50 of 27 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YL410 is a potent, selective and vivo efficacious antagonist of atypical chemokine receptor GPR15 with IC50 of 27 nM.
YL410 displays high selectivity against a panel of related GPCRs and kinases.
YL410 suppresses GPR15L-induced Jurkat T-cell migration, and exhibits favorable pharmacokinetics and acceptable safety.
YL410 induces significant weight loss and exerts blood glucose-lowering effects in diet-induced obesity (DIO) mouse model.

Physicochemical Properties

M.Wt	512.63
Formula	C28H28N6O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(6-(2-methylmorpholino)pyridin-3-yl)-N-(1-(4-(oxazol-2-yl)phenyl)cyclopropyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-amine

References

1. Huang C, et al. Angew Chem Int Ed Engl. 2026 Oct 12:e6947632.

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YL410 (YL-410)

Biological Activity

Physicochemical Properties

References

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