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CCX662

Chemical Structure : CCX662

CAS No.: 1226686-54-9

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CCX662 (CCX-662)

Catalog No.: PC-28385Not For Human Use, Lab Use Only.

CCX662 (CCX-662) is a potent, selective CXCR7 (ACKR3) inhibitor with IC50 of 9 nM (buffer) and 18 nM (100% human serum), and rat IC50 of 14 nM (100% rat serum), blocks CXCL12 binding to CXCR7, inhibits CXCR4-directed trans-endothelial migration of CXCR4+/CXCR7+ cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CCX662 (CCX-662) is a potent, selective CXCR7 (ACKR3) inhibitor with IC50 of 9 nM (buffer) and 18 nM (100% human serum), and rat IC50 of 14 nM (100% rat serum), blocks CXCL12 binding to CXCR7, inhibits CXCR4-directed trans-endothelial migration of CXCR4+/CXCR7+ cells.

Physicochemical Properties

M.Wt 539.69
Formula C28H37N5O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Butanoic acid, 4-[[8-[hexahydro-4-[[2-(4-hydroxy-1-piperidinyl)-4-thiazolyl]methyl]-1H-1,4-diazepin-1-yl]-6-methyl-7-quinolinyl]oxy]-

References

1. Patent WO2010/054006 A1.

2. Walters MJ, et al. Br J Cancer. 2014;110(5):1179-1188.

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