Chemical Structure : CXCR3 antagonist 7D
CAS No.:
2416213-45-9
CXCR3 antagonist 7D
Catalog No.: PC-23096Not For Human Use, Lab Use Only.
CXCR3 antagonist 7D is a specific small molecule CXCR3 antagonist, inhibits CXCL4-mediated DENV2 replication with EC50 of 2.1 uM in monocytic U937-DC-SIGN cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CXCR3 antagonist 7D is a specific small molecule CXCR3 antagonist, inhibits CXCL4-mediated DENV2 replication with EC50 of 2.1 uM in monocytic U937-DC-SIGN cells.
7D (5μM) suppressed the CXCL4-mediated enhancement of DENV2 replication, similar to the effect of AMG487.
7D inhibits the replication of all other serotypes DENV1, DENV3 and DENV4 in vitro.
7D increased IFN synthesis via CXCR3 axis in vitro.
7D improves dengue disease pathology and mice survivability alongside increases IFN synthesis, enhances DENV2-specific antibodies in infected mice.
Physicochemical Properties
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M.Wt
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536.63
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Formula
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C32H32N4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1-cyclohexyl-2-(4-methoxyphenyl)-1H-benzo[d]imidazole-5-carbonyl)-L-tryptophan
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References
1. Gaur KK, et al. EMBO Mol Med. 2024 Sep 16. doi: 10.1038/s44321-024-00137-8.
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