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Cat. No. Product Name Information
PC-20524

GNE-149

ER degrader

GNE-149 (GNE149) is a potent, full estrogen receptor alpha (ERα) antagonist and degrader with IC50 of 0.053 nM (MCF7, ERα degradation).
PC-20417

SLU-PP-1072

ERRα/γ inhibitor

SLU-PP-1072 is a potent, selective, dual ERRα/γ inverse agonist, inhibits ERRα- and ERRγ-dependent transcription in cotransfection assays with IC50 of 4.8 and 0.9 uM.
PC-20415

GSK4716

ERRγ agonist

GSK4716 (GSK 4716) is a selective agonist of estrogen-related receptors ERRβ and ERRγ with EC50 of 1.3 uM (ERRγ).
PC-20414

DY131

ERRγ agonist

DY131 (GSK 9089) is a selective agonist of the ERRβ/γ receptor with EC50 of 130 nM, does not affect the ERRα, ERα and β (IC50>30 uM).
PC-49172

H3B-6545 hydrochloride

ERα antagonist

H3B-6545 hydrochloride is a potent, covalent antagonist of both wild-type and mutant estrogen receptor alpha (ERα), shows antiproliferative activity for ERαWT and ERαY537S overexpressing MCF7 cells with or without H524 L ESR1 mutation with low nM IC50 values.
PC-38780

LX-039

SERD

LX-039 is a novel potent, oral and selective estrogen receptor degrader (SERD) with profound anti-tumor activity, desirable ER antagonistic characteristics.
PC-38514

WAY-169916

ER inhibitor

WAY-169916 is an orally active pathway-selective estrogen receptor (ER) ligand, inhibiting NF-kB transcriptional activity (IC50=93 nM), but is devoid of conventional estrogenic activity.
PC-38372

Rintodestrant

SERD

Rintodestrant (G1T48) is a potent, oral selective estrogen receptor degrader (SERD) with EC50 of 0.24 nM (ERα degradation, ICW), competitively binds to and degrades estrogen receptor (ER) and blocks ER signaling in ER-positive breast cancer cells.
PC-73405

Bexirestrant

Estrogen Receptor inhibitor

Bexirestrant is an orally active ER-α degrader with antineoplastic effect.
PC-72139

BC-N102

Estrogen Receptor inhibitor

BC-N102 is a first-in-class novel small molecule inhibitor for targeting oncogenic and hormonal signaling in ER-positive breast cancer.
PC-35861

THIQ 40

THIQ 40 (THIQ40) is a potent, orally available ERα antagonist and selective estrogen receptor degrader (SERD) with IC50 of 17 nM (ERα binding) and 30 nM (ERα transcription), IC50 of 0.9 nM (ERα degradation).
PC-35243

OP-1074

OP-1074 (OP1074) is a potent, selective ER degrader (SERD), shows specific antiestrogenic activity for both ERα and ERβ, inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC50 of 1.6 and 3.2 nM, respectively.

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