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Chemical Structure : XCT790
CAS No.: 725247-18-7
Catalog No.: PC-42580Not For Human Use, Lab Use Only.
XCT790 (XCT-790) is a potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $28 | In stock | |
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | Get quote |
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XCT790 (XCT-790) is a potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.
XCT790 shows no significant antagonist activity on related nuclear receptors (ERRγ or ERα, LXRα, LXRβ, FXR, PPARα, PPARδ, PPARγ, Nurr1, RARα, RORα, and RXRα) at 10 uM.
XCT790 inhibits PGC-1α regulation of ERRα and ERRα target gene expression.
XCT790 inhibits proliferation in cellular models of breast cancer.
| M.Wt | 596.4249 | |
| Formula | C23H13F9N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 21 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]- |
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1. Willy PJ, et al. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8912-7.
2. Busch BB, et al. J Med Chem. 2004 Nov 4;47(23):5593-6.
3. Lanvin O, et al. J Biol Chem. 2007 Sep 28;282(39):28328-34.
4. Chang CY, et al. Cancer Cell. 2011 Oct 18;20(4):500-10.
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