XCT790 (XCT-790) is a potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.
XCT790 shows no significant antagonist activity on related nuclear receptors (ERRγ or ERα, LXRα, LXRβ, FXR, PPARα, PPARδ, PPARγ, Nurr1, RARα, RORα, and RXRα) at 10 uM.
XCT790 inhibits PGC-1α regulation of ERRα and ERRα target gene expression.
XCT790 inhibits proliferation in cellular models of breast cancer.
