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Chemical Structure : PHTPP
CAS No.: 805239-56-9
Catalog No.: PC-60267Not For Human Use, Lab Use Only.
PHTPP is a potent, selective antagonist of estrogen ERβ receptor, exhibits 36-fold selective for ERβ.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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PHTPP is a potent, selective antagonist of estrogen ERβ receptor, exhibits 36-fold selective for ERβ.
PHTPP is fully effective as an ERα antagonist, while exhibiting no significant agonism on ERβ or Erα.
PHTPP enhances SKOV3 and OV2008 ovarian cancer cell growth in in vitro assays.
| M.Wt | 423.3 | |
| Formula | C20H11F6N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol |
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1. Compton DR, et al. J Med Chem. 2004 Nov 18;47(24):5872-93.
2. Chan KK, et al. J Endocrinol. 2014 May 12;221(2):325-36.
3. Kajta M, et al. Neuroscience. 2013 May 15;238:345-60.
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