PHTPP

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Chemical Structure : PHTPP

CAS No.: 805239-56-9

Catalog No.: PC-60267Not For Human Use, Lab Use Only.

PHTPP is a potent, selective antagonist of estrogen ERβ receptor, exhibits 36-fold selective for ERβ.

Packing	Price	Stock
5 mg (Free Sample)	$28	In stock
25 mg	$138	In stock
50 mg	$228	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PHTPP is a potent, selective antagonist of estrogen ERβ receptor, exhibits 36-fold selective for ERβ.
PHTPP is fully effective as an ERα antagonist, while exhibiting no significant agonism on ERβ or Erα.
PHTPP enhances SKOV3 and OV2008 ovarian cancer cell growth in in vitro assays.

Physicochemical Properties

M.Wt	423.3
Formula	C20H11F6N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol

References

1. Compton DR, et al. J Med Chem. 2004 Nov 18;47(24):5872-93.

2. Chan KK, et al. J Endocrinol. 2014 May 12;221(2):325-36.

3. Kajta M, et al. Neuroscience. 2013 May 15;238:345-60.

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PHTPP

Biological Activity

Physicochemical Properties

References

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