Chemical Structure : 4-Hydroxytamoxifen
CAS No.: 68392-35-8
Catalog No.: PC-70134Not For Human Use, Lab Use Only.
4-Hydroxytamoxifen (Afimoxifene) is a selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.
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4-Hydroxytamoxifen (Afimoxifene) is a selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.
4-Hydroxytamoxifen exhibits more potent estrogen agonist/antagonist activity and can inhibit MCF-7 and MDA-MB-231 cell proliferation with IC50 values of 27 and 18 uM, respectively.
M.Wt | 387.5139 | |
Formula | C26H29NO2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol |
1. Mansel R, et al. Breast Cancer Res Treat. 2007 Dec;106(3):389-97.
2. Desta Z, et al. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
3. Seeger H, et al. Horm Metab Res. 2004 May;36(5):277-80.
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