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4-Hydroxytamoxifen

Chemical Structure : 4-Hydroxytamoxifen

CAS No.: 68392-35-8

4-Hydroxytamoxifen (Afimoxifene)

Catalog No.: PC-70134Not For Human Use, Lab Use Only.

4-Hydroxytamoxifen (Afimoxifene) is a selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

4-Hydroxytamoxifen (Afimoxifene) is a  selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.
4-Hydroxytamoxifen exhibits more potent estrogen agonist/antagonist activity and can inhibit MCF-7 and MDA-MB-231 cell proliferation with IC50 values of 27 and 18 uM, respectively.

 

Physicochemical Properties

M.Wt 387.5139
Formula C26H29NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol

References

1. Mansel R, et al. Breast Cancer Res Treat. 2007 Dec;106(3):389-97.

2. Desta Z, et al. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.

3. Seeger H, et al. Horm Metab Res. 2004 May;36(5):277-80.

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