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Enclomiphene citrate

Chemical Structure : Enclomiphene citrate

CAS No.: 7599-79-3

Enclomiphene citrate ((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476)

Catalog No.: PC-60063Not For Human Use, Lab Use Only.

Enclomiphene citrate ((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476) is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Enclomiphene citrate ((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476) is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism.
Enclomiphene citrate inhibits the ER in the pituitary gland, reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, increases gonadotropin secretion and hence gonadal production of testosterone.

Physicochemical Properties

M.Wt 598.089
Formula C32H36ClNO8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-2-(4-(2-chloro-1,2-diphenylvinyl)phenoxy)-N,N-diethylethan-1-amine 2-hydroxypropane-1,2,3-tricarboxylate

References

1. Hill S, et al. IDrugs. 2009 Feb;12(2):109-19.

2. Marth C, et al. Biochem Pharmacol. 1984 Dec 15;33(24):3951-6.

3. Wilcox JN, et al. Brain Res. 1983 May 5;266(2):243-51.

4. Huang ES, et al. Endocrinology. 1983 Feb;112(2):442-8.

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