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Enclomiphene citrate

Chemical Structure : Enclomiphene citrate

CAS No.: 7599-79-3

Enclomiphene citrate ((E)-Clomifene;cis-Clomifene;RMI-16289;ICI-46476)

Catalog No.: PC-60063Not For Human Use, Lab Use Only.

Enclomiphene citrate((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476) is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Enclomiphene citrate((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476) is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism; inhibits the ER in the pituitary gland, reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, increases gonadotropin secretion and hence gonadal production of testosterone.

Sexual Dysfunction

Phase 3 Clinical

Physicochemical Properties

M.Wt 598.089
Formula C32H36ClNO8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-2-(4-(2-chloro-1,2-diphenylvinyl)phenoxy)-N,N-diethylethan-1-amine 2-hydroxypropane-1,2,3-tricarboxylate

References

1. Hill S, et al. IDrugs. 2009 Feb;12(2):109-19.

2. Marth C, et al. Biochem Pharmacol. 1984 Dec 15;33(24):3951-6.

3. Wilcox JN, et al. Brain Res. 1983 May 5;266(2):243-51.

4. Huang ES, et al. Endocrinology. 1983 Feb;112(2):442-8.

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