| Cat. No. |
Product Name |
Information |
| PC-49158 |
JND003
ERRα agonist
|
JND003 is a potent, selective and orally bioavailable ERRα agonist with EC50 of 86.0 nM for enhancing the interaction between ERRα and PGC1α peptide in AlphaScreen assays, exhibits an EC50 value of 2.7 uM in AAB-Luc cells stably expressing ERRα luciferase reporter. |
| PC-38780 |
LX-039
SERD
|
LX-039 is a novel potent, oral and selective estrogen receptor degrader (SERD) with binding IC50 of 0.99 nM, MCF7 antiproliferation IC50 of 3.76 nM. |
| PC-38372 |
Rintodestrant
SERD
|
Rintodestrant (G1T48) is a potent, oral selective estrogen receptor degrader (SERD) with EC50 of 0.24 nM (ERα degradation, ICW), competitively binds to and degrades estrogen receptor (ER) and blocks ER signaling in ER-positive breast cancer cells. |
| PC-73421 |
Imlunestrant
SERD and ER inhibitor
|
Imlunestrant (LY3484356) is a potent, oral, selective estrogen receptor degrader (SERD) and pure estrogen receptor antagonist with Ki values of 0.64 nM and 2.8 nM against WT ERα and Y537S mutant ERα proteins, respectively. |
| PC-73108 |
SAR439859
SERD
|
SAR439859 (Amcenestrant) is a potent, orally available, selective estrogen receptor degrader (SERD) with IC50 of 0.2 nM (ERα degradation). |
| PC-73046 |
GNE-274
ER partial agonist
|
GNE-274 (GNE274) is a small molecule non-degrader, partial agonist of estrogen receptor (ER), failed to trigger increased ER turnover in tested cell line. |
| PC-72965 |
GSK5182
ERRγ inverse agonist
|
GSK5182 (GSK-5182) is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with IC50 of 79 nM. |
| PC-72964 |
DN200434
ERRγ inverse agonist
|
DN200434 (DN-200434) is a highly potent (functional IC50=6 nM, binding IC50=40 nM), selective, biocompatible and orally available ERRγ inverse agonist. |
| PC-72914 |
TTC-352
ER mimic agonist
|
TTC-352 (TTC352) is a synthetic selective estrogen mimic acts as estrogen receptor (ER) partial agonist for the treatment of endocrine-resistant breast cancer. |
| PC-72844 |
ErSO
UPR activator
|
ErSO is a small molecule activator of the unfolded protein response (UPR), activates the a-UPR, induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro. |
| PC-72786 |
Giredestrant
SERD
|
GDC-9545 (Giredestrant) is an efficient and potent selective estrogen receptor degrader (SERD) and a full antagonist. |
| PC-72665 |
GNE-502
ER antagonist
|
GNE-502 (GNE502) is an orally bioavailable and potent degrader for estrogen receptor positive breast cancer. |
