| Cat. No. |
Product Name |
Information |
| PC-72964 |
DN200434
ERRγ inverse agonist
|
DN200434 (DN-200434) is a highly potent (functional IC50=6 nM, binding IC50=40 nM), selective, biocompatible and orally available ERRγ inverse agonist. |
| PC-72914 |
TTC-352
ER mimic agonist
|
TTC-352 (TTC352) is a synthetic selective estrogen mimic acts as estrogen receptor (ER) partial agonist for the treatment of endocrine-resistant breast cancer. |
| PC-72844 |
ErSO
UPR activator
|
ErSO is a small molecule activator of the unfolded protein response (UPR), activates the a-UPR, induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro. |
| PC-72786 |
GDC-9545
SERD
|
GDC-9545 (Giredestrant) is an efficient and potent selective estrogen receptor degrader (SERD) and a full antagonist. |
| PC-72665 |
GNE-502
ER antagonist
|
GNE-502 (GNE502) is an orally bioavailable and potent degrader for estrogen receptor positive breast cancer. |
| PC-72606 |
Camizestrant
SERD
|
AZD9833 (Camizestrant) is an orally bioavailable, highly potent, next-generation selective estrogen receptor degrader (SERD) and antagonist with both EC50 of <1 nM (ERα receptor) in MCF7 cells. |
| PC-35861 |
THIQ 40
ERα inhibitor
|
THIQ 40 (THIQ40) is a potent, orally available ERα antagonist and selective estrogen receptor degrader (SERD) with IC50 of 17 nM (ERα binding) and 30 nM (ERα transcription), IC50 of 0.9 nM (ERα degradation). |
| PC-35370 |
LY500307
ERβ agonist
|
LY500307 (LY-500307, Erteberel, SERBA-1) is a potent, selective Estrogen Receptor β (ERβ) agonist with Ki/EC50 of 0.19/0.66 nM, 12-fold higher affinity than ERα and exhibits 32-fold more functional potency. |
| PC-35365 |
H3B-5942
ERα inhibitor
|
H3B-5942 is an orally available, selective estrogen receptor covalent antagonist (SERCA) with Ki 1 nM and 0.41 nM for wild-type and mutant ERα Y537S respectively, covalently targeting Cys530. |
| PC-35243 |
OP-1074
SERD
|
OP-1074 (OP1074) is a potent, selective ER degrader (SERD), shows specific antiestrogenic activity for both ERα and ERβ, inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC50 of 1.6 and 3.2 nM, respectively. |
| PC-63294 |
GDC-0927
SERD
|
GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) with IC50 of 0.1 nM (ER-α degradation) and Emax=97%. |
| PC-63293 |
LSZ102
|
LSZ102 is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) with ERα transcription IC50 of 6 nM and ERα degradation IC50 of 0.2 nM. |
