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DN200434

Chemical Structure : DN200434

CAS No.: 2170732-60-0

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DN200434 (DN-200434, DN 200434)

Catalog No.: PC-72964Not For Human Use, Lab Use Only.

DN200434 (DN-200434) is a highly potent (functional IC50=6 nM, binding IC50=40 nM), selective, biocompatible and orally available ERRγ inverse agonist.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DN200434 (DN-200434) is a highly potent (functional IC50=6 nM, binding IC50=40 nM), selective, biocompatible and orally available ERRγ inverse agonist.
    DN200434 binds to key ERRγ binding pocket residues through four-way interactions.
    DN200434 effectively upregulated iodide-handling genes and restored radioiodine avidity in ATC tumor lesions.
    DN200434 enhanced ATC tumor radioiodine therapy susceptibility, markedly inhibiting tumor growth.
    DN200434 shows higher potency than GSK5182.

    Physicochemical Properties

    M.Wt 456.63
    Formula C30H36N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (δE)-δ-[(4-Hydroxyphenyl)[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methylene]benzenebutanol

    References

    1. Thoudam Debraj Singh, et al. Clin Cancer Res. 2019 Aug 15;25(16):5069-5081.

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