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Chemical Structure : DN200434
Catalog No.: PC-72964Not For Human Use, Lab Use Only.
DN200434 (DN-200434) is a highly potent (functional IC50=6 nM, binding IC50=40 nM), selective, biocompatible and orally available ERRγ inverse agonist.
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DN200434 (DN-200434) is a highly potent (functional IC50=6 nM, binding IC50=40 nM), selective, biocompatible and orally available ERRγ inverse agonist.
DN200434 binds to key ERRγ binding pocket residues through four-way interactions.
DN200434 effectively upregulated iodide-handling genes and restored radioiodine avidity in ATC tumor lesions.
DN200434 enhanced ATC tumor radioiodine therapy susceptibility, markedly inhibiting tumor growth.
DN200434 shows higher potency than GSK5182.
| M.Wt | 456.63 | |
| Formula | C30H36N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thoudam Debraj Singh, et al. Clin Cancer Res. 2019 Aug 15;25(16):5069-5081.
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