Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : GNE-274
Catalog No.: PC-73046Not For Human Use, Lab Use Only.
GNE-274 (GNE274) is a small molecule non-degrader, partial agonist of estrogen receptor (ER), failed to trigger increased ER turnover in tested cell line.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
GNE-274 (GNE274) is a small molecule non-degrader, partial agonist of estrogen receptor (ER), failed to trigger increased ER turnover in tested cell line.
GNE-274 potently inhibited cellular proliferation of ER+ HER2-negative cell lines, induced an LBD antagonist conformation similar to GDC-0927, neither promotes the degree of anti-proliferative activity achieved by GDC-0927.
GNE-274 displays considerable transcriptional agonism, GNE-274 increased chromatin accessibility at 373 induced ER binding site.
| M.Wt | 457.57 | |
| Formula | C29H31NO4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Guan J, et al. Cell. 2019 Aug 8;178(4):949-963.e18.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
