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Chemical Structure : GNE-274
Catalog No.: PC-73046Not For Human Use, Lab Use Only.
GNE-274 (GNE274) is a small molecule non-degrader, partial agonist of estrogen receptor (ER), failed to trigger increased ER turnover in tested cell line.
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GNE-274 (GNE274) is a small molecule non-degrader, partial agonist of estrogen receptor (ER), failed to trigger increased ER turnover in tested cell line.
GNE-274 potently inhibited cellular proliferation of ER+ HER2-negative cell lines, induced an LBD antagonist conformation similar to GDC-0927, neither promotes the degree of anti-proliferative activity achieved by GDC-0927.
GNE-274 displays considerable transcriptional agonism, GNE-274 increased chromatin accessibility at 373 induced ER binding site.
| M.Wt | 457.57 | |
| Formula | C29H31NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guan J, et al. Cell. 2019 Aug 8;178(4):949-963.e18.
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