Cat. No. |
Product Name |
Information |
PC-21008 |
CIDD-0149897
ERβ agonist
|
CIDD-0149897 is a potent, selective, brain permeable estrogen receptor beta (ERβ) agonist, 40-fold selective over ERα. |
PC-20982 |
SLU-PP-915
ERR agonist
|
SLU-PP-915 is a potent pan-ERR (Estrogen-related receptor) nuclear receptor agonist with EC50 of 414/435/378 nM for ERRα/ERRβ/ERRγ, respectively. |
PC-20547 |
Palazestrant
Estrogen receptor inhibitor
|
Palazestrant (OP-1250) is a potent, orally bioavailable complete estrogen receptor (ER) antagonist (IC50=6.4 nM) and selective ER degrader, blocks activity of both AF1 and AF2. |
PC-20416 |
SLU-PP-332
ERR agonist
|
SLU-PP-332 is a potent, selective pan ERRα/β/γ agonist with EC50 of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, in full-length ERR cell-based cotransfection/reporter assays. |
PC-49259 |
SMIP34
PELP1 inhibitor
|
SMIP34 (Small Molecule Inhibitor of PELP1 34) is a first-in-class, small molecule inhibitor of estrogen receptor (ER) coregulator PELP1, binds to (Kd=37.4 uM) and reduces PELP1 oncogenic functions. |
PC-49171 |
H3B-6545
ERα antagonist
|
H3B-6545 is a potent, covalent antagonist of both wild-type and mutant estrogen receptor alpha (ERα), shows antiproliferative activity for ERαWT and ERαY537S overexpressing MCF7 cells with or without H524 L ESR1 mutation with low nM IC50 values. |
PC-49158 |
JND003
ERRα agonist
|
JND003 is a potent, selective and orally bioavailable ERRα agonist with EC50 of 86.0 nM for enhancing the interaction between ERRα and PGC1α peptide in AlphaScreen assays, exhibits an EC50 value of 2.7 uM in AAB-Luc cells stably expressing ERRα luciferase reporter. |
PC-38780 |
LX-039
SERD
|
LX-039 is a novel potent, oral and selective estrogen receptor degrader (SERD) with binding IC50 of 0.99 nM, MCF7 antiproliferation IC50 of 3.76 nM. |
PC-73421 |
Imlunestrant
SERD and ER inhibitor
|
Imlunestrant (LY 3484356) is a potent, oral, selective estrogen receptor degrader (SERD) and pure estrogen receptor antagonist with Ki values of 0.64 nM and 2.8 nM against WT ERα and Y537S mutant ERα proteins, respectively. |
PC-73108 |
SAR439859
SERD
|
SAR439859 (Amcenestrant) is a potent, orally available, selective estrogen receptor degrader (SERD) with IC50 of 0.2 nM (ERα degradation). |
PC-73046 |
GNE-274
ER partial agonist
|
GNE-274 (GNE274) is a small molecule non-degrader, partial agonist of estrogen receptor (ER), failed to trigger increased ER turnover in tested cell line. |
PC-72965 |
GSK5182
ERRγ inverse agonist
|
GSK5182 (GSK-5182) is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with IC50 of 79 nM. |