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Sironestrant

Chemical Structure : Sironestrant

CAS No.: 2735803-90-2

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Sironestrant (SIM0270, SIM-0270)

Catalog No.: PC-27501Not For Human Use, Lab Use Only.

Sironestrant (SIM0270) is a brain-penetrant, oral selective estrogen receptor degrader (SERD), induces sustained inhibition of ER-dependent gene transcription and cell growth, shows antitumor activity in ESR1-mutant models and brain-metastatic models.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Sironestrant (SIM0270) is a brain-penetrant, oral selective estrogen receptor degrader (SERD), induces sustained inhibition of ER-dependent gene transcription and cell growth, shows antitumor activity in ESR1-mutant models and brain-metastatic models.

Physicochemical Properties

M.Wt 489.56
Formula C26H31F4N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Pyridinamine, N-[(3S)-1-(3-fluoropropyl)-3-pyrrolidinyl]-6-[(1S,3R)-2,3,4,9-tetrahydro-3-methyl-2-(2,2,2-trifluoroethyl)-1H-pyrido[3,4-b]indol-1-yl]-

References

1. Patent WO2021228210 A1 2021-11-18.

2. Jian Zhang, et al. Clin Cancer Res (2025) 31 (12_Supplement): PS14-04.

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