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LX-039

Chemical Structure : LX-039

CAS No.: 2135341-09-0

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LX-039 (LX039)

Catalog No.: PC-38780Not For Human Use, Lab Use Only.

LX-039 is a novel potent, oral and selective estrogen receptor degrader (SERD) with binding IC50 of 0.99 nM, MCF7 antiproliferation IC50 of 3.76 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LX-039 is a novel potent, oral and selective estrogen receptor degrader (SERD) with binding IC50 of 0.99 nM, MCF7 antiproliferation IC50 of 3.76 nM.
    LX-039 exhibits profound anti-tumor activity, desirable ER antagonistic characteristics combined with favorable pharmacokinetic and preliminary safety properties.

    Physicochemical Properties

    M.Wt 480.360
    Formula C27H20Cl2FNO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-[4-[2-(2-Chloro-4-fluorophenyl)-1-(3-chloro-1H-indol-2-yl)-1-buten-1-yl]phenyl]-2-propenoic acid

    References

    1. Jianyu Lu, et al. Bioorg Med Chem Lett. 2022 Jun 15;66:128734.

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