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JND003

Chemical Structure : JND003

CAS No.: 1187568-16-6

JND003 (JND 003)

Catalog No.: PC-49158Not For Human Use, Lab Use Only.

JND003 is a potent, selective and orally bioavailable ERRα agonist with EC50 of 86.0 nM for enhancing the interaction between ERRα and PGC1α peptide in AlphaScreen assays, exhibits an EC50 value of 2.7 uM in AAB-Luc cells stably expressing ERRα luciferase reporter.

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    Biological Activity

    JND003 is a potent, selective and orally bioavailable ERRα agonist with EC50 of 86.0 nM for enhancing the interaction between ERRα and PGC1α peptide in AlphaScreen assays, exhibits an EC50 value of 2.7 uM in AAB-Luc cells stably expressing ERRα luciferase reporter.
    JND003 (5.0 μM) potently and selectively agonizes the transcriptional function of ERRα in AAB-Luc cells, displays no obvious effect on ERRβ and ERRγ, as well as other nuclear hormone receptors, such as ERα, ERβ, ERγ and PPARγ.
    JND003 (10.0 μM) reduces lipid accumulation and enhances fatty acid oxidization in HepG2-IR cells.
    JND003(30mg/kg, oral) exhibits high grade of distribution in liver and abdominal adipose tissues, improves insulin sensitivity, alleviates liver steatosis and serum lipid disorders in HFD-fed C57 mice.

    Physicochemical Properties

    M.Wt 266.300
    Formula C16H14N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    7-methoxy-3-methyl-2-phenyl-4(3H)-Quinazolinone

    References

    1. Liufeng Mao, et al. ACS Bio Med Chem Au. 2022 Jun 15;2(3):282-296.

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