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Rintodestrant

Chemical Structure : Rintodestrant

CAS No.: 2088518-51-6

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Rintodestrant (G1T48)

Catalog No.: PC-38372Not For Human Use, Lab Use Only.

Rintodestrant (G1T48) is a potent, oral selective estrogen receptor degrader (SERD) with EC50 of 0.24 nM (ERα degradation, ICW), competitively binds to and degrades estrogen receptor (ER) and blocks ER signaling in ER-positive breast cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Rintodestrant (G1T48) is a potent, oral selective estrogen receptor degrader (SERD) with EC50 of 0.24 nM (ERα degradation, ICW), competitively binds to and degrades estrogen receptor (ER) and blocks ER signaling in ER-positive breast cancer cells.

    Physicochemical Properties

    M.Wt 462.491
    Formula C26H19FO5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-3-(4-((2-(4-fluoro-2,6-dimethylbenzoyl)-6-hydroxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

    References

    1. Philippe Aftimos, et al. Cancer Res (2021) 81 (4_Supplement): PS12-04.

    2. Kaitlyn J Andreano, et al. Breast Cancer Res Treat. 2020 Apr;180(3):635-646.

    3. Xiong R, et al. J Med Chem. 2017;60(4):1325–1342.

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