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Droloxifene

Chemical Structure : Droloxifene

CAS No.: 82413-20-5

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Droloxifene (3-Hydroxytamoxifen;FK-435)

Catalog No.: PC-70133Not For Human Use, Lab Use Only.

Droloxifene (3-Hydroxytamoxifen; FK-435) is a nonsteroidal selective estrogen receptor modulator (SERM) that shows 10- to 60-fold increased affinity for the estrogen receptor compared with Tamoxifen.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Droloxifene (3-Hydroxytamoxifen; FK-435) is a nonsteroidal selective estrogen receptor modulator (SERM) that shows 10- to 60-fold increased affinity for the estrogen receptor compared with Tamoxifen.
Droloxifene has reduced partial estrogen agonistic activity.

Physicochemical Properties

M.Wt 387.52
Formula C26H29NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol

References

1. Rauschning W, et al. Breast Cancer Res Treat. 1994;31(1):83-94.

2. Hasmann M, et al. Cancer Lett. 1994 Sep 15;84(2):101-16.

3. Leng Y, et al. Eur J Pharmacol. 2000 Dec 8;409(2):123-31.

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