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Chemical Structure : AZD9496 maleate
CAS No.: 1639042-28-6
Catalog No.: PC-43271Not For Human Use, Lab Use Only.
A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $120 | In stock | |
| 10 mg | $208 | In stock | |
| 50 mg | $720 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68; shows pM equipotent binding to both ERα and ERβ isoforms, highly selective binding compared with progesterone (∼650-fold), glucocorticoid (∼11,223-fold), and androgen (∼36,375-fold) receptor LBDs; downregulator of ERα in vitro and in vivo in ER-positive models of breast cancer and orally available.
Breast Cancer
Phase 1 Clinical
| M.Wt | 558.5456 | |
| Formula | C29H29F3N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Propenoic acid, 3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-, (2E)-, (2Z)-2-butenedioate (1:1) |
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1. De Savi C, et al. J Med Chem. 2015 Oct 22;58(20):8128-40.
2. Weir HM, et al. Cancer Res. 2016 Jun 1;76(11):3307-18.
3. Toy W, et al. Cancer Discov. 2017 Mar;7(3):277-287.
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